
He has a stepdaughter from his wife Medha Manjrekar's first husband. They have a daughter, Saiee Manjrekar, who is an actress. Manjrekar was married to Deepa Mehta, a costume designer but they were divorced with whom he has two children.

He was a MNS candidate from Mumbai North West in the 2014 Lok Sabha Elections but lost to Gajanan Kirtikar of Shiv Sena.

Manjrekar was acclaimed for the role as inspector D.R. He also played the role of Harpeez Dongara in the Aakhri Chunauti series of episodes in the Indian TV series C.I.D. He played Chatrapati Shivaji Maharaj in the Marathi film Me Shivajiraje Bhosale Boltoy. He first gained acclaim as an actor for his performance in the 2002 film Kaante, and later played negative roles in the Tamil film Arrambam (2013), Telugu film Okkadunnadu (2007) and as the gangster Javed in the film Slumdog Millionaire (2008).

He was first seen in the Door darshan Marathi series named Kshitij, in which he played a leprosy patient. Manjrekar has acted in several films, including some of his own productions.
